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In their heyday, from the Swinging Sixties and into the Seventies, these drugs were increasingly expected by patients, and prescribed by doctors, for almost any stress, however minor. But no convincing endodiazepine has yet appeared and Squires, one of the discoverers of the benzodiazepine receptor, believes that there is no endogenous ligand and no reason to assume that one exists. His bosses urged him to forget tranquilizers and move on to antibiotics.

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For years, profits from his inventions accounted for 40 percent of LaRoches annual drug sales. Valium diazepam may increase the effects of other drugs that cause drowsiness, including antidepressants, alcohol, antihistamines, sedatives used to treat insomnia, pain relievers, anxiety medicines, seizure medicines, and muscle relaxants.
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